Click mediated synthesis of functionalized glycolipids with peptide-peptoid linkages

The present work describes the synthesis of a new class glycolipids with systematic variation in linkage region as well aglycon part using Cu(I) catalyzed click reaction. between sugar and was diversified amide, amido-triazole, 5-benzoyl triazole moieties. structural diversity further amplified by incorporating several polar peptide foldamer groups such triazole, peptide, or N-aryl peptoid it. newly designed were derived from amalgamation different bond mimics. This reports first use glycolipids. synthesized characterized spectroscopic spectrometric analyses. impact amide ring on morphology analyzed comparing their self-assembly SEM analysis. geometries also optimized density functional theory structures found to be minima potential energy surfaces.